摘要目的:调查白血病患儿内化和外化行为问题现状，并分析其影响因素。方法:横断面研究。选取2021年11月至2022年3月在郑州市3所医院小儿血液肿瘤内科就诊的符合纳入和排除标准的121例白血病患儿及照顾者为调查对象。采用一般资料调查表、长处与困难问卷(父母版)、心理适应量表、Zarit护理负担量表和领悟社会支持量表进行调查。采用多元线性回归分析白血病患儿内化和外化行为的影响因素。结果:121例白血病患儿中，男72例，女49例；年龄(7.16±3.81)岁。其内化行为问题得分为(6.12±3.13)分，外化行为问题得分为(5.49±2.92)分。多元线性回归分析显示，护理负担( β＝0.412， P<0.001)、家庭支持( β＝－0.242， P＝0.003)和家庭人均月收入( β＝－0.167， P＝0.036)是白血病患儿内化行为问题的影响因素；护理负担( β＝0.360， P<0.001)、社交能力( β＝－0.223， P＝0.008)和照顾者年龄( β＝－0.176， P＝0.035)是白血病患儿外化行为问题的影响因素。 结论:白血病患儿的内化和外化行为问题较严重，照顾者护理负担、家庭支持和社交能力对患儿不良情绪行为问题具有一定预测价值。

abstractsObjective:To investigate internalized and externalized behavioral problems in children with leukemia and to analyze the influencing factors.Methods:A total of 121 children match the inclusion and exclusion criteria with leukemia hospitalized in Hematology and Oncology Department of 3 hospitals in Zhengzhou city from November 2021 to March 2022 were recruited through a cluster sampling method.The general information questionnaire, Strengths and Difficulties Questionnaire (parent version), Psychological Adaptation Scale, Perceived Social Support Questionnaire and Zarit Burden Interview were used for investigation.Multiple linear regression was used to analyze the influencing factors of internalized and externalized behavioral problems in children with leukemia.Results:Among 121 children with leukemia, there were 72 males and 49 females, with the age of (7.16 ± 3.18) years.The total score of interna-lized and externalized behavioral problems in 121 children with leukemia was (6.12±3.13) points and (5.49±2.92) points, respectively.Multiple linear regression analysis showed that burden of care ( β=0.412, P<0.001), family support ( β=-0.242, P=0.003) and monthly household income per capita ( β=-0.167, P=0.036) were the influencing factors of internalized behavioral problems in children with leukemia.Burden of care ( β=0.360, P<0.001), social integration ( β=-0.223, P=0.008) and caregiver age ( β=-0.176, P=0.035) were the influencing factors of externalized behavioral problems in children with leukemia. Conclusions:Children with leukemia suffer severe internalized and externalized behavioral problems.Burden of care of the caregiver, family support and social integration are predictors of adverse emotional and behavioral problems in children.