摘要目的：探讨盐酸厄洛替尼治疗晚期非小细胞肺癌过程中甲沟炎的发生及切实可行的护理干预措施。方法选择78例口服盐酸厄洛替尼治疗的晚期非小细胞肺癌患者，观察其中甲沟炎的发生情况，并评价一定的护理干预措施对甲沟炎的预防及治疗效果。结果78例口服盐酸厄洛替尼的晚期非小细胞肺癌中有7例发生不同程度的甲沟炎，并且通过护理干预措施，能够有效地预防及治疗甲沟炎。结论口服靶向药物盐酸厄洛替尼治疗晚期非小细胞肺癌，会引起甲沟炎等不良反应的发生，但通过有效的护理干预能够控制其不良反应，保证治疗的顺利进行。

abstractsObjective To explore the nursing interventions of paronychia caused by Erlotinib therapy for advanced non-small-cell lung cancer patients. Methods A total of 78 patients who diagnosed as advanced non-small-cell lung cancer and treated by oral Erlotinib were selected. The occurrence of paronychia among them was observed and the curative effect of certain nursing interventions on paronychia was evaluated. Results Seven out of 78 cases occurred various degrees of paronychia,and certain nursing interventions could effectively prevent and treat paronychia. Conclusions Targeted drug Erlotinib in patients with advanced non-small cell lung cancer can cause adverse reactions like paronychia,but effective nursing interventions are capable of controlling the adverse reactions, thus further improve the quality of life and ensure the smooth progress of treatment.