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A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer

摘要Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC).Both the Long non-coding RNA(lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1α (HIF-1α) are highly expressed in PC patients and play a crucial role in disease progression.Reciprocal regulation involving PVT1 and HIF-1α in PC,however,is poorly understood.Here,we report that PVT1 binds to the HIF-1α promoter and activates its transcription.In addition,we found that PVT1 could bind to HIF-1α and increases HIF-1α post-translationally.Our findings suggest that the PVT1-HIF-1α positive feedback loop is a potential therapeutic target in the treatment of PC.

作者 Yiping Zhu ^[1] Fang Wu ^[2] Weiwei Gui ^[3] Nan Zhang ^[2] Erik Matro ^[3] Linghua Zhu ^[1] Daniel Turunen Eserberg ^[3] Xihua Lin ^[4] 学术成果认领

作者单位 Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China ^[1] Department of Endocrinology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China ^[2] School of Medicine,Zhejiang University,Hangzhou,China ^[3] Department of Endocrinology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China;Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou,China ^[4]

关键词 PVT1 HIF-1α pancreatic cancer feedforward regulatory loop

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DOI 10.1093/jmcb/mjab042

发布时间 2022-01-19（万方平台首次上网日期，不代表论文的发表时间）

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