摘要Obese individuals even with normal glucose tolerance(NGT)are at higher risk for developing type 2 diabetes(T2D),and obesity is associated with inflammation.However,mechanisms linking inflammation to beta-cell function and insulin sensitivity in NGT individuals are not fully understood.We aimed to investigate the relationships between inflammation-related proteins(IRPs)and insulin dynamics in NGT subjects.The explorations were conducted using data from 1109 non-diabetes subjects aged 40-44 with normal or excess body weight and 21 Chinese NGT subjects aged 22-32 with accurate metabolic assessment.IRPs were detected with Olink technology.Insulin sensitivity and beta-cell function were evaluated with hyperinsulinemic-euglycemic clamp and hyperglycemic clamp.Eight associators were identified with obesity in NGT subjects,among which MCP-3,IL-6,TWEAK,HGF,and CST5 also showed associations in non-diabetes people.Four IRPs were linked to insulin sensitivity,with IL-24 being a novel finding.Seven IRPs were related to beta-cell function,including novel associators CD244,CD40,and IL-15RA.Moreover,most IRPs were interconnected,with IL-6 as the hub.In conclusion,insulin sensitivity and beta-cell function are related to IRPs involved in chemotaxis,activation of immune cells,and cell proliferation,which might provide valuable information for the understanding of the mechanisms associated with T2D pathogenesis.