摘要Cardiogenic shock(CS)is a common cause of mortality and treatment remains chal-lenging despite advances in therapeutic options.CS is caused by severe impairment of myocardial per-formance that results in decreased cardiac output,hypoperfusion of the end organ,and hypoxia.Clini-cally this presents as hypotension refractory to volume resuscitation with features of end-organ hy-poperfusion requiring pharmacological or mechanical intervention.Acute myocardial infarction(AMI)accounts for 81％of patients with CS.Heat shock protein family B member 1(HSPB1)is a multi-functional protein induced by various stress factors and has a protective effect on cells.A large number of studies have demonstrated that HSPB1 plays an important role in regulating apoptosis.Recently,some studies have suggested that HSPB1 also participates in the autophagic process.HSPB1 are ex-pressed in many cells of the cardiovascular system such as endothelial cells,cardiac muscle cells,monocytes,and platelets.They are up-regulated in response to inflammation,oxidative stress,or is-chemia and protect cells against extracellular stress factors.Here,we explore the involvement of HSPB1 in apoptosis,autophagy,and CS.We speculate that HSPB1 may exert its anti-myocardial in-jury role via the regulation of apoptosis and autophagy;this may provide the basis for the development of new approaches for the prevention and treatment of CS.