摘要Objective To explore the application effect of goal-directed fluid therapy(GDFT)on laparoscopic liver resection.Methods From July 2023 to December 2023,48 patients who under-went laparoscopic liver resection were randomly divided into the GDFT group and the CLCVP(con-trolled low central venous pressure)group.The patients in the GDFT group were guided by stroke volume variability(SVV)during surgery,while those in the CLCVP group were guided by a con-trolled low central venous pressure technique during fluid replacement surgery.Intraoperative bleeding volume,fluid replacement volume,urine output,liver blood flow obstruction time,postoperative ex-haust time,length of hospital stays,and incidence of complications were recorded and compared be-tween the two groups of patients.Results There was a difference between the two groups in terms of crystal fluid,colloid fluid,total fluid volume,and urine volume(P＞0.05).However,the bleeding volume in the GDFT group(515.61±246.71)mL was lower than that in the CLCVP group(389.37±187.35)mL(P＜0.05);and the blockade time of liver blood flow in the GDFT group(46.33±7.26)min was shorter than that of the CLCVP group(41.84±6.24)min(P＜0.05);the postop-erative exhaust time of patients in the GDFT group(4.86±1.24)d was shorter than that of patients in the CLCVP group(6.42±1.05)d(P＜0.05);the hospitalization days of patients in the GDFT group(9.21±2.15)d were fewer than those in the CLCVP group(11.04±4.29)d(P＜0.05).There were no statistically significant differences in the incidence of postoperative complications be-tween the two groups of patients(P＞0.05).Conclusion GDFT guided by SVV can stabilize intrao-perative hemodynamics in patients undergoing laparoscopic liver resection,reduce intraoperative bleed-ing,and reduce liver blood flow blockage time.It is safer and more reliable than traditional fluid ther-apy.