摘要Lower extremity arterial occlusive disease(LEASO)is a common peripheral arterial disease characterized by arterial stenosis or occlusion,leading to impaired blood flow and subsequent lower limb ischemia.This condition not only severely impacts patients'quality of life but also increases the risk of cardiovascular events and amputations.Among the underlying mechanisms,oxidative stress and endothelial dysfunction are recognized as key pathogenic mechanisms driving the onset and progression of LEASO.Oxidative stress induces cellular and tissue damage through the excessive pro-duction of reactive oxygen species(ROS),while endothelial dysfunction refers to the loss of normal physiological functions of endothelial cells.The complex interplay between these two factors signifi-cantly contributes to the progression of LEASO.Recent advances in molecular biology and biotechnol-ogy have deepened our understanding of these mechanisms,uncoverint the roles of NADPH oxidase and mitochondrial dysfunction in oxidative stress,as well as the contribution of endothelial-mesenchy-mal transition(EndMT)to endothelial dysfunction.These insights have paved the way for the devel-opment of antioxidants and endothelial protectants,offering promising new avenues for the treatment of LEASO.This article aims to review the relationship between oxidative stress,endothelial dysfunc-tion,and LEASO,highlighting their critical roles in disease progression and discussing potential ther-apeutic strategies.By reducing oxidative damage and protecting endothelial function,antioxidant ther-apy and lifestyle modifications have shown potential to slow the progression of atherosclerosis.Moreo-ver,interventions targeting oxidative stress and endothelial function are considered potential effective strategies for the treatment of LEASO.In summary,this review seeks to provide a solid theoretical basis and explore novel therapeutic strategies for the prevention and treatment of LEASO.