摘要Ischemic cardiovascular diseases(ICVDs)are the leading causes of death and disa-bility worldwide,encompassing conditions such as myocardial infarction(MI)and peripheral artery disease(PAD).The core pathological features include ischemic injury and ischemia-reperfusion(I/R)injury resulting from arterial blood supply obstruction.Although current diagnostic and therapeu-tic strategies have improved prognosis,challenges remain,such as the recurrence of acute events and long-term cardiac function preservation.In recent years,clock genes,as components of a time-regula-tion system operating from the molecular to the individual level,have attracted significant attention for their role in maintaining cardiovascular homeostasis.Core rhythm factors(such as BMAL1,CLOCK,PER2,and REV-ERBα)regulate myocardial energy metabolism,mitochondrial function,autophagy,ferroptosis,and immune-inflammatory responses,thereby playing a crucial role in the pathogenesis of ICVDs.Genetic and epigenetic evidence suggests that polymorphisms and epigenetic modifications of these genes may influence an individual's susceptibility to disease and disease progression.Preclinical studies have indicated that chronotherapy,targeted interventions in rhythm pathways,and lifestyle optimization present novel strategies for the prevention and treatment of ICVDs.This review system-atically summarizes the research progress on clock genes in ICVDs,explores their value and challenges in elucidating disease mechanisms and developing interventions,and provides insights for integrating chronomedicine into precision prevention and treatment systems.