血浆可溶性髓样细胞触发受体-1在脓毒性休克预后评估中的价值

Value of plasma soluble triggering receptor expressed on myeloid cells-1 to predicting the prognosis of septic shock

导出 LinkOut 学术成果认领

摘要目的探讨血浆可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells 1,sTREM-1)评估脓毒性休克患者预后的价值.方法 42例脓毒性休克患者均给予集束化治疗,28 d后存活33例为生存组,死亡9例为死亡组,检测并比较2组入住ICU第1、3、5天血浆sTREM-1水平,急性生理和慢性健康评分Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)及全身感染相关性器官功能衰竭评分(Sepsis-related Organ Failure Assessment,SOFA),分析sTREM-1水平与APACHEⅡ、SOFA评分的相关性.结果死亡组入住ICU第3、5天血浆sTREM-1水平[(568.49±46.02)、(603.58±28.82)ng/L]、APACHEⅡ评分(34.50±4.46、38.37±4.39)、SOFA评分(14.64±3.97、18.15±3.84)高于生存组[血浆sTREM-1(396.11±27.05)、(172.58±13.32)ng/L,APACHEⅡ评分24.59±5.86、15.46±6.67,SOFA评分10.21±1.85、6.98±2.10] (P＜0.05);Spearman相关分析结果显示,血浆sTREM-1水平与APACHEⅡ评分(r=0.472,P=0.033)、SOFA评分(r=0.528,P=0.005)呈正相关.结论血浆sTREM-1水平可用于脓毒性休克患者预后的评估.