摘要Objective To determine the role of the circulating antisperm antibody (ASA) in the pathogenesis of missed abortion at the first-trimester pregnancy.Methods Sixty-two patients with a history of missed abortion at the first-trimester pregnancy were enrolled into this study.Indirect immunobead test (IBT) was used to measure the circulating ASA levels.Fifty healthy women with the first-trimester pregnancy set as the control,Results No case had the positive level of ASA according to the World Health Organization criteria (50％ or more of the motile sperm with immunobead binding).Only 1 case in patient group and 1 case in the control had 10％-20％ of the motile spermatozoa with ASA-IgG bead binding.In both patient and control groups,ASA-IgA was found to be completely negative binding.Conclusion The circulating ASA is not associated with the pathogenesis of missed abortions at the first-trimester pregnancy.