摘要多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性最常见的生殖内分泌疾病,超重和/或肥胖可加重PCOS女性的代谢状况及生殖障碍情况.肥胖症及内脏脂肪堆积与慢性低度炎症状态相关,PCOS患者机体处于一种慢性炎症状态,炎症可诱导胰岛素抵抗(insulin resistance,IR),IR可导致高雄激素血症(IR)及雄激素增多;与此同时,IR加重机体的炎症反应状态,两者互相作用、相互影响,形成恶性循环.性激素影响体脂分布,PCOS患者中约50阿～60％的患者常表现为男性体脂分布,出现腹部脂肪积聚的表现.IR、炎症反应和腹型肥胖之间存在因果关系.腹型肥胖可能导致IR和炎症反应,IR和炎症反应的增加也会导致腹型肥胖.一般将脂肪细胞分为白色脂肪细胞和棕色脂肪细胞,白色脂肪组织(white adipose tissue,WAT)主要分布在身体的皮下和内脏,与炎症、IR和Ⅱ型糖尿病(type 2 diabetesmellitus,T2DM)强烈相关.棕色脂肪组织(brown adipose tissue,BAT)可以增加能量消耗并产生热量,主要在肩胛间、周围和主动脉区蓄积.棕色脂肪可改善PCOS的能量消耗及糖代谢状况,降低相关性激素水平,有助于改善PCOS患者的月经周期及排卵情况.

abstractsPolystic ovary syndrome (PCOS) is the most common reproductive endocrine disease in women.Overweight/obesity can aggravate the metabolic status and reproductive disorders of PCOS women.Obesity and visceral fat accumulation are associated with chronic hypo-inflammatory status,PCOS patients are in a chronic inflammatory state.Inflammation can lead to insulin resistance (IR),and IR will lead to hyperandrogenism and increased androgen.IR and inflammation interact with each other,becoming a vicious cycle.Sex hormones affect the body fat distribution,PCOS patients in about 50％ to 60％ often manifested as male body fat distribution,the emergence of abdominal fat accumulation.IR,inflammatory response and abdominal obesity have the relationship between each other.Abdominal obesity may lead to IR and inflammatory response,IR and increased inflammatory response can also lead to abdominal obesity.Traditionally,adiposities are divided into white adiposities and brown adiposities.White adipose tissue (WAT) mainly distributed in the subcutaneous and viscera of the body,and strongly correlated with inflammation,IR and type 2 diabetes mellitus (T2DM).Brown adipose tissue (BAT) can increase energy consumption and generate heat,mainly in the scapular,surrounding and aortic deposits.BAT can improve the energy consumption of PCOS and glucose metabolism,reduce the level of related hormones,help to improve the menstrual cycle of PCOS patients and ovulation.