摘要随着胚胎冷冻技术的进步,全部胚胎冷冻策略得以实现,高孕激素状态下促排卵(progestin primed ovarian stimulation,PPOS)成为可能.PPOS的理论基础是基于高孕激素能抑制黄体生成素(luteinizing hormone,LH)峰及人类卵泡募集的多个卵泡波模式,其包括利用内源性天然高孕激素的黄体期促排卵,应用外源性孕激素类药物的卵泡期高孕激素状态下促排卵,及其衍生而来的一系列方案.这些方案在国内外的研究中都已被证明能有效抑制LH峰,且能获得有发育潜能的胚胎,但对于其卫生经济学效益等仍有待研究.本文就此方案目前的研究进展作一综述.

abstractsWith the improvements of freezing embryos techiques for assisted reproductive technology (ART),freezing all the embryos after controlled ovarian hyperstimulation (COH) is realized.Thanks to the freeze-all policy,progesterone is actually used as part of the protocol,which we called the progestin primed ovarian stimulation (PPOS).The physiological principles of PPOS are the use of progesterone to block the luteinizing hormone (LH) surge and waves of folliculogenesis during the menstrual cycle.There are two ways of using progesterone,whether it be endogenous,as in luteal phase,or exogenous,as in the follicular phase.These two methods and a variety of stimulation protocols derived from them have already been proved that they do not affect the number of oocytes collected or the quality of the embryos obtained both in normal responders and poor responders,while being effective in blocking the LH surge.However,their medical and economic significance remains to be demonstrated.This paper makes a review of the progress of this new ovarian stimulation protocol here.