摘要卵母细胞质量对女性生殖功能至关重要,胰岛素抵抗(insulin resistance,IR)是影响卵母细胞质量的关键因素之一.近年来,国内外学者从不同角度、不同层面对IR影响卵母细胞质量的问题进行了一系列研究.本文就卵泡细胞包括卵母细胞、颗粒细胞、卵泡膜细胞的微观结构与功能变化,卵巢局部的缺血缺氧性损伤,以及机体其他各内分泌轴的网络联系等不同方面对IR影响卵母细胞质量的机制进行了综述;同时展望了未来需给予更多关注的研究方向,以期进一步探究二者的相互关系,并为不同IR程度、不同人群卵母细胞质量异常的患者进行个体化治疗及管理方案提供新思路.

abstractsOocyte quality is very important for female reproductive function,insulin resistance (IR) is one of crucial factors to oocyte quality.In recent years,domestic and overseas scholars,standing in different angles and different levels,have conducted a series of studies about the effects of IR on the quality of oocyte.This article reviewed mechanisms of IR affecting oocyte quality from different aspects,such as changes in the microstructure and function of follicle cells including oocyte,granulosa cells and theca cells,local hypoxic-ischemic injury of ovary,and network ties between other endocrine axes.At the same time,it summarized research directions what need more attention in the future,in order to further explore the relationship between IR and oocyte quality,and to provide new ideas for strategies of individualized treatment and management among different patients with oocyte abnormalities impacted by different IR levels.