摘要目的:评价促性腺激素释放激素(GnRH)拮抗剂方案在卵巢储备功能低下(diminished ovarian reserve，DOR)患者行体外受精-胚胎移植（ in vitrofertilization-embryo transfer，IVF-ET）中的应用效果。 方法:回顾性队列研究分析2015 年1月至2016年12月期间在西北妇女儿童医院生殖中心首次接受IVF-ET治疗的DOR患者的临床资料，根据促排卵方案不同，分为GnRH拮抗剂方案组和超短方案组。比较两组一般情况、临床及实验室指标、妊娠结局。结果:活产率、临床妊娠率、种植率组间比较差异均无统计学意义（ P>0.05）。GnRH拮抗剂方案组Gn用量[（3 082.04±1 004.40) IU]比超短方案组少[(3 510.05±1 119.09) IU]( P<0.001)，Gn使用时间[(9.66±2.13) d]比超短方案组短[(10.63±2.27) d, P<0.001]，获卵数(4.54±2.97)比超短方案组少(5.54±3.54， P<0.001)。 结论:DOR患者采用GnRH拮抗剂方案超促排卵治疗与超短方案妊娠结局相似，且Gn用量更少、Gn使用时间更短。因此，GnRH拮抗剂方案也是DOR患者适宜的促排卵方案之一。

abstractsObjective:To evaluate the effect of gonadotropin-releasing hormone antagonist (GnRH-A) protocol on in vitro fertilization-embryo transfer (IVF-ET) in patients with diminished ovarian reserve (DOR). Methods:A retrospective cohort study was performed to analyze the clinical data of the DOR patients who received IVF-ET treatment for the first time at the Northwest Women's and Children's Hospital Reproductive Center during January 2015 to December 2016. They were divided into a GnRH-A protocol group and an gonadotropin-releasing hormone agonist (GnRH-a) short protocol group according to different ovulation induction protocols. The general conditions, clinical and laboratory indicators, and pregnancy outcomes of the two groups were compared.Results:There was no statistically significant difference in live birth rate, clinical pregnancy rate and implantation rate between the two groups ( P>0.05). The dosage of gonadotropin (Gn) used in GnRH-A protocol group [(3 082.04±1 004.40) IU] was less than that in GnRH-a short protocol group [(3 510.05±1 119.09) IU], P<0.001], the duration of Gn used [(9.66±2.13) d] was shorter than that in GnRH-a short protocol group [(10.63±2.27) d, P<0.001], the number of eggs (4.54±2.97) was less than that in GnRH-a short protocol group (5.54±3.54, P<0.001). Conclusion:DOR patients using GnRH-A protocol for hyperovulation therapy have similar outcomes to GnRH-a short protocol pregnancy, with less Gn used dosage and shorter Gn used duration. Therefore, the GnRH-A protocol is also one of the suitable ovulation induction for DOR patients.