摘要目的:评估环境三氯生(2.4.4'-三氯-2'-羟基二苯醚)暴露与早发性卵巢功能不全(POI)发病的关联性。方法:本研究为病例对照研究，2014年3月至2015年12月从浙江、上海和山东三个省份的三家生殖中心门诊招募确诊的POI患者45名(POI组)和525名因男方不孕或输卵管性不孕前来就诊的患者，依据中心、年龄（±1岁）、体质量指数(BMI)(±2 kg/m 2)按照1：2的比例给POI患者在男方或输卵管性因素所致不孕的患者库中匹配对照90名（对照组），检测其尿液标本中的三氯生水平，用多元回归分析模型研究三氯生暴露与POI发病和基础内分泌激素之间的关联性。 结果:88.9%的尿液标本中检测出三氯生，浓度为1.37(0.56,3.50) ng/mg肌酐。尿中三氯生浓度与女性POI发病呈正向关联(调整后 OR=1.31;95% CI=1.00~1.70)，且有剂量反应效应。三氯生浓度与卵泡刺激素(FSH)水平之间呈正向关联(调整后 β=2.89;95% CI=0.06~5.71)。 结论:三氯生暴露可能与POI的发病风险之间有关联，但需要大样本的研究人群进一步进行验证。

abstractsObjective:To investigate the potential effects of triclosan (TCS) on premature ovarian insufficiency (POI) in women.Methods:A total of 45 POI patients and 525 women who sought fertility treatment for male factors or tubal obstruction were recruited from three reproductive centers in three provinces of China from March 2014 to December 2015. Totally 90 women who sought fertility treatment for male factors or tubal obstruction were center-age-body mass index （BMI) matched controls. TCS concentrations were quantified in urine samples. Baseline reproductive hormones were measured on the 2nd-3rd day of menstruation.Results:TCS was detected in 88.9% of women [1.37(0.56, 3.50) ng/mg creatinine]. TCS concentrations were associated with increased risk of POI (adjust OR=1.31; 95% CI=1.00-1.70). We also divided TCS concentration into quartiles in prioriand there tended to be a dose-response pattern. TCS concentrations were also positively associated with the levels of follicle-stimulating hormone （FSH) (adjust β=2.89; 95% CI=0.061-5.710). Conclusion:TCS concentrations may associate with increased risk of POI, but a large study population is needed for further verification.