子宫内膜干细胞治疗宫腔粘连的研究进展
Research progress of endometrial stem cells based therapy in intrauterine adhesions
摘要宫腔粘连患者的子宫内膜基底层受损,纤维组织增生,生育能力受到严重影响。然而,目前对中重度宫腔粘连患者的常规手术治疗术后复发率高且效果差。随着再生医学的发展,外源性移植干细胞治疗宫腔粘连取得了一定的进展,干细胞修复子宫内膜将成为一种新的宫腔粘连的治疗方式。研究表明,子宫内膜中存在干细胞,并且其参与内膜的修复与再生。本文主要对子宫内膜干细胞的研究现状和治疗宫腔粘连的进展进行综述。
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abstractsIntrauterine adhesions is a gynecological disorder characterized by endometrial basal layer damage and fibrous proliferation, which results in infertility. However, the conventional surgery therapy of intrauterine adhesions has high recurrence rates and poor effects. With the development of regenerative medicine, exogenous transplanted stem cell therapy has obtained certain curative effect on intrauterine adhesions as a new treatment. Numerous studies have demonstrated that the existence of endometrial stem cells can support the tissue maintenance/regrowth. In this review, we provide an overview of the accumulating evidence for the endometrial stem cells. We also discuss the development of endometrial stem cell therapy for intrauterine adhesions.
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