新型冠状病毒肺炎疫情对辅助生殖技术服务的影响:一项全国性横断面调查
Impacts of COVID-19 pandemics on the services of assisted reproductive technology in Chinese mainland: a national cross-sectional survey
摘要目的:了解新型冠状病毒肺炎疫情对全国不孕不育症诊疗技术——辅助生殖技术服务的影响情况,为生殖医学中心和精子库的复工复产工作提供指导性意见,以便更好地保障育龄夫妇获得生殖健康相关医疗服务。方法:2020年5月,采用线上问卷调查的方式向中国内地31个省(自治区、直辖市)已批准开展人类辅助生殖技术的517家生殖医学中心和27家人类精子库的机构负责人进行调查。主要调查内容包括:2019年及2020年1~4月各机构的辅助生殖技术服务量、开展的疫情防控措施、医患感染情况、疫情期间业务暂停及复工复产情况等。结果:本次调查共获得475家生殖医学中心和22家精子库的有效反馈,分别占全国总机构数的91.9%和81.5%。在新型冠状病毒肺炎疫情期间,63.6%(302/475)的生殖医学中心和95.5%(21/22)的精子库都受疫情影响而暂停对外业务。与2019年同期相比,2020年1~4月份生殖医学中心的门诊量、夫精人工授精周期数、供精人工授精周期数、取卵周期数、新鲜移植周期数和解冻移植周期数的下降比例分别为45.0%、46.5%、52.8%、49.2%、52.3%和37.1%(疫情最严重的湖北省下降比例在70%~90%),精子库的捐精人数和自精保存人数下降比例分别为60.7%和51.1%。全国生殖医学中心共上报了5例工作人员新型冠状病毒感染病例(均在湖北省),精子库未出现工作人员感染病例。结论:针对目前新型冠状病毒肺炎疫情防控常态化的形势,应制定专门针对生殖医学中心和精子库的疫情防控流程和新型冠状病毒筛查指南,有必要建立一个患者分层分级动态评估及管理体系,从而帮助机构在疫情防控期间迅速鉴别出来哪些患者需要向其优先提供生育治疗服务。
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abstractsObjective:To explore the impacts of COVID-19 pandemics on assisted reproductive technology (ART) services in Chinese mainland, and then to provide evidence-based guidance for the following resumption of ART centers and sperm banks.Methods:In May 2020, an online questionnaire survey was conducted in all 517 ART centers and 27 sperm banks from all 31 provinces in Chinese mainland. The services number of different technologies in 2019 and 2020 (from January to April), the epidemic prevention and control measures have being taken, infectious numbers of medical workers and patients seeking for ART services, and situations about the business suspension and resumption during the epidemic period in these institutions were surveyed.Results:Among all surveyed institutions, there were 475 ART centers (91.9%) and 22 sperm banks (81.5%) that completed the online questionnaire. Totally, 63.6% (302/475) of ART centers and 95.5% (21/22) of sperm banks suspended services due to the outbreak of COVID-19. The comparison between the period from January to April in 2020 and that in 2019 showed that the total number of outpatients, artificial insemination with husband semen (AIH) cycles, artificial inseminaton with donor semen (AID) cycles, aspiration cycles, fresh embryo transfer cycles, and frozen embryo transfer (FET) cycles decreased by 45.0%, 46.5%, 52.8%, 49.2%, 52.3% and 37.1% (70%-90% in Hubei Province as the hardest-hit area), and that the total number of sperm donors and those seeking self-sperm preservation decreased by 60.7% and 51.1%. A total of 5 medical staff infected with COVID-19 were reported by ART centers and all cases were in Hubei Province; none of infected cases among medical staff was reported by sperm banks.Conclusion:During the "new normal" period of COVID-19, it is urgent to develop specific COVID-19 prevention and control procedures and screening guidelines for ART centers and sperm banks. It is necessary to establish a dynamic hierarchical evaluation and management system for ART patients, in order to efficiently identify those patients who need fertility treatment services with priority.
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