摘要克氏综合征是男性不育中最常见的染色体异常疾病，还可引起发育障碍、认知障碍、雄激素缺乏和代谢综合征等疾病。目前其早期筛查和诊断率较低。克氏综合征引起的男性不育主要通过睾丸显微取精术/辅助生殖技术助孕。本文旨在对克氏综合征的早期筛查诊断和不育症诊疗策略进行综述，重点探讨克氏综合征患者早期筛查诊断和生育相关治疗等相关问题。

abstractsKlinefelter's syndrome (KS) is the most common chromosomal abnormality in male infertility, which could also lead to developmental disorders, cognitive disorders, androgen deficiency, metabolic syndrome and other diseases. However, the early screening and diagnosis rate of KS is still low. KS related male infertility is mainly treated by microdissection testicular sperm extraction (MD-TESE)/assisted reproductive technology (ART). We aimed to review the diagnosis and treatment strategies of KS and mainly focused on screening and the treatment to male infertility of patients with KS.