摘要氧化应激是氧化与抗氧化的失衡状态，活性氧参与了生殖系统生理病理过程。核因子E2相关因子2/抗氧化反应元件（nuclear factor erythroid 2 related factor 2/antioxidant response element，Nrf2/ARE）是重要的抗氧化应激通路，Nrf2可被诸多因素如活性氧、抗氧化剂等激活进入细胞核，与小Maf蛋白和ARE结合，调控多种抗氧化酶的表达，从而发挥抗氧化作用。研究表明，Nrf2/ARE抗氧化通路在生殖系统疾病中发挥了重要的调控作用。本文就近年来国内外关于Nrf2/ARE信号通路在生殖系统中的研究进展进行综述，并对存在的问题及今后研究方向进行探讨及展望。

abstractsOxidative stress is the imbalance between oxidation and anti-oxidation, and reactive oxygen species participate in the physiological and pathological process of reproductive system. Nuclear factor erythroid 2 related factor 2/antioxidant response element (Nrf2/ARE) is an important antioxidant stress pathway. Nrf2 can be activated into the nucleus by various factors such as reactive oxygen species and antioxidants, and combine with small Maf protein and ARE to regulate the expression of various antioxidant enzymes, thus playing an antioxidant role. Studies have shown that the Nrf2/ARE antioxidant pathway plays an important regulatory role in reproductive system diseases. In this paper, the research progress of Nrf2/ARE signaling pathway in reproductive system at home and abroad in recent years is reviewed, and the existing problems and future research directions are discussed and prospected.