摘要内分泌干扰物（endocrine disrupting chemicals，EDCs）是一种新型持久性的有机污染物，人们通过皮肤、消化道、呼吸道等途径不可避免地暴露于EDCs，大量研究表明EDCs可损害生殖系统、中枢神经系统、心血管系统、免疫系统以及内分泌系统，因此亟待开展干预EDCs毒性的药物研究。双酚A、邻苯二甲酸二（2-乙基己基）酯、重金属、丙烯酰胺是常见的EDCs，本文将对这些常见EDCs诱发的生殖损伤及现今相关药物干预研究进行总结概述，以期为开发更多干预EDCs的药物提供理论依据。

abstractsEndocrine disrupting chemicals (EDCs) are a new type of persistent organic pollutant. Humans are inevitably exposed to EDCs through multiple routes of skin, digestive tract, and respiratory tract. Several studies indicate that EDCs impair the reproductive system, central nervous system, cardiovascular system, immune system, and endocrine system. Therefore, it is urgent to carry out drug research to interfere with the toxicity of EDCs. Bisphenol A, di-(2-ethylhexyl) phthalate, heavy metals, and acrylamide are common endocrine disruptors. This article will summarize these common endocrine disruptors-induced reproductive damage and the current drug intervention studies, expecting to provide some theoretical support for the development of more drugs to interfere with EDCs.