摘要胚胎植入依赖于良好的胚胎质量、子宫内膜容受性,及胚胎-子宫内膜间同步和谐地交流对话。相较于发展较成熟的胚胎培养技术,目前子宫内膜容受性仍缺乏有效的诊断与治疗方法,传统检测方法如胞饮突检测、组织学检测、超声等,其准确性和可重复性饱受质疑。随着组学技术的发展,利用基因表达的整体特征描述、诊疗疾病已成为可能,其在子宫内膜容受性领域也具有较大的研究和临床运用价值。本文就近年来子宫内膜容受性领域转录组学临床研究作一综述,概括子宫内膜容受性相关编码基因、非编码基因研究的基本情况及临床运用情况,为后续研究子宫内膜容受性、指导临床诊疗提供参考。
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abstractsEmbryo implantation is a complex process that relies on elaborate cooperation between the well-qualified embryo and endometrial receptivity, and synchronous and harmonious communication between embryo and endometrium. Compared with the well-developed embryo culturing technology, there is a lack of effective diagnosis and treatment of endometrial receptivity. Traditional diagnostic tools, including pinopode analyzing, histologic dating, ultrasound, etc. are being questioned for accuracy and reproducibility. However, with the great development of omics, describing diseases in a gene expression whole pattern becomes feasible, which shows potential clinical value. The review focuses on the research progress of transcriptomic study in endometrial receptivity and concludes receptivity-related coding and non-coding RNAs, laying foundations for further research and clinical applications.
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