摘要近年来，越来越多的研究表明自噬与女性生殖过程密切相关。自噬是真核生物中广泛存在且高度保守的降解系统，可以在缺氧、饥饿、缺乏营养或极端pH值等条件下启动。在生殖健康方面，自噬可以通过清除受损细胞器，调节细胞生长代谢从而改善生殖功能障碍，适当的自噬调控有助于提高卵母细胞质量、延缓卵巢的衰老、精细调控子宫内膜的生长，确保胚胎成功着床，但自噬通路的异常可能会造成盆腔炎性细胞因子激活、子宫内膜容受性降低、卵泡发育异常以及滋养细胞的侵袭能力减弱等问题，从而导致子宫内膜异位症、慢性子宫内膜炎、多囊卵巢综合征、早发性卵巢功能不全、复发性流产等生殖障碍性疾病的发生、发展。本文综述自噬在女性生殖相关疾病中的作用机制以及治疗靶点，为改善女性生殖健康提供临床思路及诊疗策略。

abstractsIn recent years, more and more studies have shown that autophagy is closely related to female reproductive process. Autophagy is a widespread and highly conserved degradation system in eukaryotes that can be activated under conditions such as hypoxia, starvation, lack of nutrients, or extreme pH. In terms of reproductive health, autophagy can improve reproductive dysfunction by removing damaged organelles and regulating cell growth and metabolism. Appropriate regulation of autophagy helps to improve oocyte quality, delay ovarian aging, fine-regulate endometrial growth, and ensure successful implantation of embryos. However, the abnormality of autophagy pathway may cause problems such as activation of pelvic inflammatory cytokines, reduced endometrial receptivity, abnormal follicle development, and weakened invasion ability of trophoblast cells, thus leading to the occurrence and development of reproductive disorders such as endometriosis, chronic endometritis, polycystic ovary syndrome, early-onset ovarian insufficiency, and recurrent spontaneous abortion. This article reviews the mechanism and therapeutic targets of autophagy in female reproductive diseases, providing clinical ideas and diagnosis and treatment strategies for improving female reproductive health.