摘要Objective:Trem(triggering receptor expressed on myeloid cells)-1 is a novel activating receptor of the Ig super-family.In this study,we evaluated the levels of soluble Trem-1(sTrem-1)in peritoneal fluid(PF)and serum,to in-vestigate the role of Trem-1 in the pathogenesis and pathophysiology of endometriosis(EMS).Methods:The contents of sTrata-1 protein in sara and peritoneal fluid were measured in 21 women with EMS and 11 women without EMS by ELISA,and the expression of Trem-1 mRNA in the peripheral leucocytes in 6 women with EMS and 6 women without EMS by real-time PCR as well as RT-PCR.The expression of Trem-1 pro-tein in the ectopic endometrium of 6 women with EMS and without EMS was evaluated by immunohistochemical a-nalysis.Results:The concentration of strata-1 protein in PF from women with and without EMS were 33.60± 5.14 ng/ml and 14.60±3.13 ng/ml,respectively.There were significant differences in strata-1 levels in PF and serum between EMS patients and control(P<0.01).The expression of Tram-1 mRNA in the women with and without EMS was 0.77 ± 0.02 and 0.70±0.04,respectively.There was also significant difference between the two groups(P<0.05).But,there was not positive expression of Trem-1 in the ectopic endometrium.Conclusion:The expression of Trem-1 in women with EMS was up-regulated,suggesting that Tram-1 might play some important role in the pathogenesis and pathophysiology of EMS.