Expression of Mouse Telomerase Catalytic Subunit mTERT Gene in Testis of SD Rats and Its Significance

二维码有效期 120s

摘要To study the expression of mTERT gene in the testis of SD rats and its significance, insitu hybridization (ISH) techniques were used to detect the expression of telomerase gene mTERTmRNA in the testis of SD rats. The expression of mTERT was detectable in different-age male SDrats' testis. There was a positive correlation between the expression of mTERT and the location ofgerm cells (spermatogonia, spermatocyte, spermatid). In Sertoli cells, leydig cell and spermato-zoa, telomerase mTERT was not detected. Type A spermatogonia expressed the highest level of te-lomerase mTERT mRNA. Our results suggest that the expression of mTERT gene in the testis ofSD rats is of lifetime and coincide with the telomerase activity.

作者 叶哲伟 ^[1] 陈晓春 ^[2] 杨述华 ^[1] 陈江 ^[2] 熊雅丽 ^[3] 鲁功成 ^[2] 学术成果认领

作者单位 Department of Orthopedics, Xiehe hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030 ^[1] Department of Urology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology. Wuhah 430030 ^[2] Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 ^[3]

关键词 telomerase in situ hybridization germ cell gene expression

分类号 R318

发布时间 2003-12-19

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