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Probability Prediction in Multistate Survival Models for Patients with Chronic Myeloid Leukaemia

摘要In order to find an appropriate model suitable for a multistate survival experiment, 634 patients with chronic myeloid leukaemia (CML) were selected to illustrate the method of analysis.After transplantation, there were 4 possible situations for a patient: disease free, relapse but still alive, death before relapse, and death after relapse. The last 3 events were considered as treatment failure. The results showed that the risk of death before relapse was higher than that of the relapse,especially in the first year after transplantation with competing-risk method. The result of patients with relapse time less than 12 months was much poor by the Kaplan-Meier method. And the multistate survival models were developed, which were detailed and informative based on the analysis of competing risks and Kaplan-Meier analysis. With the multistate survival models, a further analysis on conditional probability was made for patients who were disease free and still alive at month 12 after transplantation. It was concluded that it was possible for an individual patient to predict the 4 possible probabilities at any time. Also the prognoses for relapse either death or not and death either before or afterrelapse may be given. Furthermore, the conditional probabilities for patients who were disease free and still alive in a given time after transplantation can be predicted.

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作者单位 Faculty of Preventive Medicine, Xiamen University Medical College, Xiamen 361005, China [1] Department of Medical Statistics, Leiden University Medical Centre, The Netherlands [2]
分类号 R73(肿瘤学)
发布时间 2005-03-31(万方平台首次上网日期,不代表论文的发表时间)
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