摘要Objective:To explore the clinical value of ultrasound shear wave elastography(SWE)and contrast-enhanced ultrasound(CEUS)in transrectal prostate biopsy.Methods:A total of 54 patients(average age:67.79±12.01 years)in the experimental group underwent transrectal prostate biopsy under the guidance of SWE,while 46 patients(average age:69.22±11.54 years)in the control group underwent transrectal prostate biopsy guided by CEUS.Results:There were a total of 451 needles,with an average of 8.35±1.67 needles per patient in the experimental group,and a total of 462 needles,with an average of 10.04±1.33 needles per patient in the control group.The difference in puncture times between the two groups was statistically significant(P＜0.05).There was no significant difference in the positive detection rate,sensitivity or specificity between the two groups(P＞0.05),but there was a significant difference in the diagnostic accuracy between the two groups(P＜0.05).The Emean and Emax of prostate cancer were significantly higher in the experimental group than in benign prostatic hyperplasia(P＜0.05).The receiver operating characteristic curve(ROC)analysis showed that the area under the ROC curve(AUC)of Emean was 0.752(S.E.=0.072,95％CI=0.611-0.894,P=0.007),and the best cutoff value was 47.005 kPa.Conclusion:In summary,both SWE-and CEUS-guided transrectal prostate biopsy can help find the focus and guide the puncture,and improve the positive detection rate.