摘要To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and older.Methods:This single-center retrospective cohort study enrolled consecutive COVID-19 patients aged 60 years old and older,who were admitted to Liyuan Hospital from January 1,2020 to April 25,2020.All included patients were divided into two groups:hypertension and nonhypertension group.The baseline demographic characteristics,laboratory test results,chest computed tomography(CT)images and clinical outcomes were collected and analyzed.The prognostic value of hypertension was determined using binary logistic regression.Results:Among the 232 patients included in the analysis,105(45.3％)patients had comorbid hypertension.Compared to the nonhypertension group,patients in the hypertension group had higher neutrophil-to-lymphocyte ratios,red cell distribution widths,lactate dehydrogenase,high-sensitivity C-reactive protein,D-dimer and severity of lung lesion,and lower lymphocyte counts(all P＜0.05).Furthermore,the hypertension group had a higher proportion of intensive care unit admissions[24(22.9％)vs.14(11.0％),P=0.02)and deaths[16(15.2％)vs.3(2.4％),P＜0.001]and a significantly lower probability of survival(P＜0.001)than the nonhypertension group.Hypertension(OR:4.540,95％CI:1.203-17.129,P=0.026)was independently correlated with all-cause in-hospital death in elderly patients with COVID-19.Conclusion:The elderly COVID-19 patients with hypertension tend to have worse conditions at baseline than those without hypertension.Hypertension may be an independent prognostic factor of poor clinical outcome in elderly COVID-19 patients.