摘要Objective:To compare survival outcomes between primary radical surgery and primary radiation in early cervical cancer.Methods:Patient information was extracted from the Surveillance,Epidemiology,and Results database.Patients diagnosed with early cervical cancer of stage T1a,T1b,and T2a(American Joint Committee on Cancer,7th edition)from 1998 to 2015 were included in this study after propensity score matching.Overall survival(OS)was analyzed using the Kaplan-Meier method.Results:Among the 4964 patients included in the study,1080 patients were identified as having positive lymph nodes(N1),and 3884 patients were identified as having negative lymph nodes(N0).Patients with primary surgery had significantly longer 5-year OS than those with primary radiotherapy in both the N1 group(P＜0.001)and N0 group(P＜0.001).In the subgroup analysis,similar results were found in patients with positive lymph nodes of stage T1a(100.0％vs.61.1％),T1b(84.1％vs.64.3％),and T2a(74.4％vs.63.8％).In patients with T1b1 and T2a1,primary surgery resulted in longer OS than primary radiation,but not in patients with T1b2 and T2a2.In multivariate analysis,the primary treatment was identified as an independent prognostic factor in both N1 and N0 patients(HRN1=2.522,95％CI=1.919-3.054,PN1＜0.001;HRN0=1.895,95％CI=1.689-2.126,PN0＜0.001).Conclusion:In early cervical cancer stage T1a,T1b1,and T2a1,primary surgery may result in longer OS than primary radiation for patients with and without lymph node metastasis.