换一批
换一批Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks
摘要篇首： MAJOR POINTS OF THE COMMENTED ARTICLE Cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes has been reported in hepatocellular carcinomas (HCCs) from China, Japan, and Korea. In this issue of the World Journal of Gastroenterology,Martins et al[1] report an analysis of LOH and microsatellite instability in HCCs from a group of 20 southern African blacks. Six known tumor suppressor genes-p53, RB1, BRCA1, BRCA2,WT1, and E-cadherin-were analyzed for LOH. In addition, the p53 gene was analyzed for the codon 249 mutation that is commonly found in subjects exposed to high levels of dietary aflatoxin B1.
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