Familial gastric cancers with Li-Fraumeni Syndrome: A case repast

二维码有效期 120s

摘要篇首： TO THE EDITORAlthough the incidence of gastric cancer has declined somewhat in recent years, it remains one of the most common cancers worldwide[1], and is the most common cancer in East Asian countries such as Korea and Japan[2].In terms of the genetics of gastric cancer, mutations in CDH1 (E-cadberin) have been associated with hereditary diffuse gastric cancer (HDGC). The first germline mutation in CDH1 was reported in a large Maori HDGC family[1],with subsequent corroborations in Western and Asian HDGC families[3-5], CDH1 mutations are believed to be associated with up to 50% of HDGC families[5], but have not been linked with sporadic or intestinal types of gastric cancer[5].

作者单位 Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center,Seoul National University, Seoul, South Korea; Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea ^[1]

关键词 Familial gastric cancers Li-Fraumeni syndrome TP53 mutation

分类号 R73

发布时间 2006-07-31

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