摘要AIM: Recent laboratory and epidemiological studies suggest that vitamin D is a potential agent for colorectal cancer prevention. Its function is partially mediated by the vitamin D receptor (VDR). The aim of this study was polymorphism (Tru9I) in the VDR intron 8 region is associated with risk for colorectal adenoma in a colonoscopy-based case-control study.METHODS: Genotyping for a total of 391 subjects was carried out through PCR and restriction fragment length polymorphism.were associated with decreased risk for adenoma (OR,0.71; 95%CI, 0.40-1.25). The inverse association was more pronounced for multiple adenomas and adenomas that were larger had moderate or greater dysplasia, or were sessile: the odds ratios (ORs) were, 0.51 (95%CI,0.21-1.24), 0.37 (95%CI, 0.11-1.28), 0.68 (95%CI, 0.33-1.41), and 0.36 (95%CI, 0.13-0.97) respectively. In joint/combined analyses, inverse associations were more obvious were younger (OR, 0.60; 95%CI, 0.26-1.37), women (OR,0.38; 95%CI, 0.17-0.88), did not smoke (OR, 0.39; 95%CI,0.13-1.23), or took NSAID (OR, 0.38; 95%CI, 0.12-1.25),but no evidence existed for interactions with calcium or vitamin D intake.CONCLUSION: Our findings suggest that the VDR Tru9Ipolymorphism may be associated with lower risk for colorectal adenoma, particularly in interaction with various risk factors, but not with calcium or vitamin D.