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Autoimmune liver disease and the Canadian First Nations Aboriginal Communities of British Columbia's Pacific Northwest

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摘要Primary biliary cirrhosis (PBC) is a well-known but uncommon chronic liver disease that is presumed to be of autoimmune etiology. Recently, investigations in British Columbia (BC), a province of Canada situated along the Pacific North-West of North America, have suggested that PBC is not a rare disease amongst BC's Aboriginal (i.e. First Nations) communities. Geographically, BC is adjacent to South East Alaska, an American state that has also reported an increased prevalence of PBC amongst its Aboriginal communities. In this article, the medical evidence supporting a hypothesis of increased risk of PBC amongst BC's First Nations communities is reviewed. Evidence suggesting that autoimmune hepatitis is also more likely amongst BC's First Nations communities is also presented.(C)2006 The WJG Press. All rights reserved.

作者单位 Department of Medicine, University of British Columbia, Vancouver, BC, Canada ^[1] Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada ^[2] Department of Medical Genetics, the University of British Columbia, Vancouver, BC, Canada ^[3]

关键词 Primary biliary cirrhosis Aboriginal First Nations British Columbia

分类号 R5

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发布时间 2006-08-04（万方平台首次上网日期，不代表论文的发表时间）

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