摘要AIM:To study the effect of albumin administration on lung injury in trauma/hemorrhagic shock (T/HS).METHODS:Sixty experimental animals were randomly divided into three groups: rats undergoing laparotomy without shock (T/SS); rats with T/HS and resuscitation with blood plus twice the volume of shed blood as Ringer's lactate (RL), and rats with T/HS and resuscitation with blood plus additional 3 Ml of 50 g/L human albumin.Expression of polymorphonuclear neutrophil (PMN) CD11b/CD18, intercellular adhesion molecule-1 (ICAM-1) of jugular vein blood and the severity of lung injuries [determined mainly by measuring activity of lung tissue myeloperoxidase (MPO) and lung injury score (LIS)] were measured after a 3-h recovery period.RESULTS:All three groups showed a significant difference in the expressions of CD11b/CD18, ICAM-1,and severity of lung injury. The expressions of CD11b/CD18 in T/SS group, T/HS + RL group, T/HS + albumin group were 17.76% ± 2.11%, 31.25% ± 3.48%,20.36% ± 3.21%, respectively (F = 6.25, P ＜ 0.05).The expressions of ICAM-1 (U/Ml) in T/SS group, T/HS + RL group, T/HS + albumin group were 258.76 ±98.23, 356.23 ± 65.6, 301.01 ± 63.21, respectively (F =5.86, P ＜ 0.05). The expressions of MPO (U/g)) in T/SS group, T/HS + RL group, T/HS + albumin group were 2.53 ± 0.11, 4.63 ± 1.31, 4.26 ± 1.12, respectively (F= 6.26, P ＜ 0.05). Moreover, LTS in T/HS + RL group,T/HS + albumin group was 2.62 ± 0.23, 1.25 ± 0.24,respectively. The expressions of CD11b/CD18, ICAM-1 and MPO in T/HS + RL group were significantly increased compared to T/SS group (P = 0.025, P = 0.036, P = 0.028,respectively). However, administration of 3 Ml of 50 g/L albumin significantly down-regulated the expressions of CD11b/CD18, ICAM-1 and lung injury index (MPO and LIS) when compared with the T/HS + RL rats (P = 0.035,P = 0.046, P = 0.038, P = 0.012, respectively).CONCLUSION:The infusion of albumin during resuscitation period can protect lung from injury and decrease the expressions of CD11b/CD18, ICAM-1 in T/HS rats.