换一批
换一批摘要CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori ( H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
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分类号
R5
栏目名称
REVIEW
DOI
10.3748/wjg.15.2855
发布时间
2009-07-22
基金项目
The National Institutes of Health Grant
the Texas Board of Higher Education
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- 被引16
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