摘要AIM: To explore the feasibility of dual camera capsule (DCC) small-bowel (SB) imaging and to examine if two cameras complement each other to detect more SB lesions. METHODS: Forty-one eligible, consecutive patients underwent DCC SB imaging. Two experienced investigators examined the videos and compared the total number of detected lesions to the number of lesions detected by each camera separately. Examination tolerability was assessed using a questionnaire. RESULTS: One patient was excluded. DCC cameras detected 68 positive findings (POS) in 20 (50%) cases. Fifty of them were detected by the "yellow" camera, 48 by the "green" and 28 by both cameras; 44% (n = 22) of the "yellow" camera's POS were not detected by the "green" camera and 42% (n = 20) of the "green" camera's POS were not detected by the "yellow" camera. In two cases, only one camera detected significant findings. All participants had 216 findings of unknown significance (FUS). The "yellow", "green" and both cameras detected 171, 161, and 116 FUS, respectively; 32% (n = 55) of the "yellow" camera's FUS were not detected by the "green" camera and 28% (n = 45) of the "green" camera's FUS were not detected by the "yellow" camera. There were no complications related to the examination, and 97.6% of the patients would repeat the examination, if necessary. CONCLUSION: DCC SB examination is feasible and well tolerated. The two cameras complement each other to detect more SB lesions.