摘要As the largest organ of the body,the skin acts as a barrier to prevent diseases and harbors a variety of beneficial bacteria.Furthermore,the skin bacterial microbiota plays a vital role in health and disease.Disruption of the barrier or an imbalance between symbionts and pathogens can lead to skin disorders or even systemic diseases.In this review,we first provide an overview of research on skin bacterial microbiota and human health,including the composition of skin bacteria in a healthy state,as well as skin bacterial microbiota educating the immune system and preventing the invasion of pathogens.We then discuss the diseases that result from skin microbial dysbiosis,including atopic dermatitis,common acne,chronic wounds,psoriasis,viral transmission,cutaneous lupus,cutaneous lymphoma,and hidradenitis suppurativa.Finally,we highlight the progress that utilizes skin microorganisms for disease therapeutics,such as bacteriotherapy and skin microbiome trans-plantation.A deeper knowledge of the interaction between human health and disease and the homeostasis of the skin bacterial microbiota will lead to new insights and strategies for exploiting skin bacteria as a novel therapeutic target.