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Gene expression profile favoring phenotypic reversion:a clue for mechanism of tumor suppression by NF-IL6 3'UTR

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摘要Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6(NF-IL6 3'UTR)induced tumor suppression in a human hepatoma cell line.cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase,nor to inactivation ofoncogenes; rather,all the changes in expression of known genes,induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy.Therefore,our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile.

作者单位 State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ^[1] Key Laboratory of Proteomics,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ^[2]

关键词 cDNA array NF-IL6 hepatoma 3'UTR tumor suppression

分类号 Q2（细胞生物学）

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SHORT COMMUNICATION

DOI 10.1038/sj.cr.7290195

发布时间 2004-04-09（万方平台首次上网日期，不代表论文的发表时间）

基金项目

国家自然科学基金（(39970172)） :Creation Foundation from Shanghai Intsitutes for Biological Sciences

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