换一批摘要Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors,mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have been linked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG binding proteins in brain development and function. This mini-review summarizes the recent advances in studying the diverse functions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of the vertebrate nervous system.
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关键词
MeCP2MBD proteinsDNA methylationneuronal differentiationchromatin remodelinggene silencinghistone modification
分类号
R3（基础医学）
DOI
10.1038/sj.cr.7290294
发布时间
2005-06-16（万方平台首次上网日期，不代表论文的发表时间）
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