换一批摘要Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurode-generative disorders. Trinucleotide repeats are located in non-coding and coding regions of the genome. Studies of bacteria, yeast, mice and man have helped to unravel some features of the mechanism of trinucleotide expansion. Looped DNA structures comprising trinucleotide repeats are processed during replication and/or repair to generate deletions or expansions. Most in vivo data are consistent with a model in which expansion and deletion occur by differ-ent mechanisms. In mammals, microsatellite instability is complex and appears to he influenced by genetic, epigenetic and developmental factors.
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关键词
microsatellite instabilitytrinucleotide repeatsbase excision repairbreak repairOGG1Huntington's diseasemyotonic dystrophy
分类号
Q2（细胞生物学）
栏目名称
DOI
10.1038/cr.2008.5
发布时间
2009-04-29（万方平台首次上网日期，不代表论文的发表时间）
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