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Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3

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作者单位 VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China;The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241 ^[1] Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, Grand Rapids, Michigan, USA ^[2] VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China ^[3] VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China;Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, Grand Rapids, Michigan, USA;Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Hubei 430074, China ^[4] VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China;Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, Grand Rapids, Michigan, USA ^[5]

关键词 Strigolactones D14 D3 GR24 receptor/co-receptor

栏目名称

ORIGINAL ARTICLES

DOI 10.1038/cr.2015.122

发布时间 2015-12-10（万方平台首次上网日期，不代表论文的发表时间）

基金项目

:This work was supported by the Van Andel Research Institute,Amway (China), the National Natural Science Foundation of China(NSFC 31300245 and NSFC 91217311). the Ministry of Science and Technology of China (2012ZX09301001, 2012CB910403,2013CB910600, XDB08020303, and 2013ZX09507001). and the Nati We thank staff members of the Life Science Collaborative Access Team of the Advanced Photon Source （(APS) for assistance in data collection at the beam lines of sector 21, which is in part funded by the Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor (085P1000817)） Use of APS was supported by the Office of Science of the US Department of Energy, under contract （no DE-AC02-06CH11357）