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MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis

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作者单位 Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China;Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA ^[1] Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA ^[2] Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA ^[3]

关键词 trinucleotide repeat expansion MutSβ DNA polymerase β (CAG)n·(CTG)n hairpin

栏目名称

ORIGINAL ARTICLES

DOI 10.1038/cr.2016.66

发布时间 2016-08-16（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This work was supported in part by the National Institutes of Health of the United States （(GM089684 to GML%GM099874 to ML). and the National Natural Science Foundation of China (31370766)） by the Joint NSFC-ISF Research Program,jointly funded by the National Natural Science Foundation of China and the Israel Science Foundation （(31461143005)） :by Tsinghua-Peking Joint Center for Life Sciences,and by the University of Southern California Norris Comprehensive Cancer Center JG is supported by a postdoctoral grant （(2015M570079)） :from the Ministry of Human Resources and Social Security of the People's Republic of China