摘要目的 了解抑郁症患者的家庭功能和家庭成员的生活质量.方法 采用家庭关怀度指数问卷(APGAR)和健康状况问卷(SF-36),对96例符合DSM-Ⅳ标准的抑郁症患者的家庭功能和家庭成员的生活质量进行评定,并与一般家庭作对照,从家庭的角度评价抑郁症的疾病负担.结果 抑郁症患者患病后家庭功能存在障碍的家庭均显著多于对照组,差异具有统计学意义(62.5％比17.3％;x2=68.125,P＜0.05),患病后比患病前家庭功能出现障碍的比例显著升高,差异具有统计学意义(62.5％比24.0％;x2=118.387,P＜0.01).经配对检验,患病后APGAR总分及各因子分均比患病前显著降低(t分别为10.874,7.330,11.649,8.240,11.797,10.162;P ＜0.01).家庭成员生活质量评定,在SF-36的8个因子中,生理职能(t=6.024,P＜0.01)、一般健康(t=12.254,P＜0.01)、社会功能(t=11.225,P＜0.01)、情感职能(t=10.328,P＜0.01)和精神健康(t=14.625,P＜0.01)因子评分显著低于对照组,生理机能(t=1.856,P＞0.05)、躯体疼痛(t=1.114,P＞0.05)、精力(t=0.032,P＞0.05)三个因子评分差异无统计学意义.结论 抑郁症对家庭功能和家庭成员生活质量的影响是严重和多层次的,需进行相应干预.

abstractsObjective To study the family function of depressive patients and the quality of life of caregivers.Methods 96 depressive patients who met with DSM-Ⅳ criteria were investigated with Family APGAR Index (APGAR) and Short Form 36 Health Survey Questionnaire (SF-36),and the data were compared with common family.Disease burden was evaluated from the aspect of family.Results Compiared with the general families,there was obvious dysfunction in depressive patients' families(62.5％ vs 17.3％ ;x2 =68.125,P＜0.01 ).There were significant differences in the dysfunction families propartion between pre-morbid and postmorbid(62.5％ vs 24.0％;x2 ＝118.387,P ＜ 0.01 ).The total scores and factor scores of APGAR in premorbid (7.51 ±2.25) were higher than post-morbid (4.27 ±3.03) (t =10.874,P＜0.01).All other factors was less thanthoee in pre-morbid (t =7.330,11.649,8.240,11.797,10.162,respectively,P ＜ 0.01 ).The scores of five factors,role-physical( t =6.024,P ＜0.01 ),general health( t =12.254,P ＜ 0.01 ),social functioning(t ＝ 11.225,P ＜ 0.01 ),role-emotional ( t =10.328,P ＜ 0.01 ) and mental health ( t =14.625,P ＜0.01 ) of SF-36 were lower than those in control group.Conclusions The family burden of depression was serious and multiple,we must pay close attention to the family function and the quality of life of care-givers and give comprehensive intervention.