摘要目的 探讨连续性肾脏替代治疗(CRRT)临时性导管封管后导管堵塞的影响因素.方法 收集2015年7月—2016年3月在浙江省人民医院ICU进行CRRT治疗的811患者资料进行回顾性分析,探讨CRRT临时性导管堵塞的影响因素.结果 811例患者CRRT治疗期间导管通畅755例,发生导管阻塞的患者56例占6.9%.单因素分析显示,APTT、PLT、抗凝方式、糖尿病和抗凝剂5个变量有统计学意义(t/χ2值分别为5.133、6.092、53.548、10.646、4.765;P<0.05).Logistic多元线性回归分析显示,PLT、糖尿病史、APTT、抗凝方式是导管封管后导管堵塞的影响因素.结论 CRRT临时性导管封管后导管堵塞的主要影响因素为PLT、糖尿病史、APTT、抗凝方式,但仍需要进一步进行大样本量的多中心研究.

abstractsObjective To investigate the influence factors of temporary catheter obstruction after sealing in the CRRT.Methods A total of 811 patients undergoing the CRRT in ICU of our hospital from July 2015 to March 2016 were included in the study. Retrospective analysis was used to investigate the influence factors of CRRT temporary catheter obstruction.Results A number of 755 out of 811 patients were catheter unobstructed,while 56 cases (6.9%) had catheter obstruction. Single factor analysis showed that 5 factors including APTT,PLT,modes of anticoagulation,diabetes and anticoagulants,had statistically significant (t/χ2=5.133,6.092,53.548,10.646,4.765;P<0.05). Logistic multivariate linear regression analysis showed that PLT,history of diabetes,APTT and modes of anticoagulation were influence factors of catheter obstruction after sealing.Conclusions The main influences factors of the CRRT temporary catheter occlusion after sealing were PLT,diabetes,APTT and modes of anticoagulation. However,further multicenter study with large sample size is necessary.