摘要目的 用Meta分析的方法探讨中药外敷治疗乳腺增生的效果.方法 全面检索公开发表在国内外杂志上关于中药外敷治疗乳腺增生的相关文献,采用统一的疗效评价标准纳入文献,收集文献中药外敷和其他疗法治疗乳腺增生的总人数及有效人数,并对文献进行质量评价,使用Review Manager 5.3软件进行Meta分析,计算合并OR值及95%可信区间(CI).结果 最终纳入研究文献共11篇,研究对象945例.运用中药外敷为464例,有效率为89.22%;对照组共治疗人数有481例,有效率为82.33%.中药外敷治疗乳腺增生的效果与中成药口服、按摩、灸法等疗法效果相当[OR=1.91,95%CI(0.74~4.97)].在中药外敷与乳癖消口服治疗乳腺增生有效性比较中,共纳入6篇文献,纳入研究对象509例,中药外敷为258例,有效率为97.29%.而采用乳癖消口服治疗例数为251例,有效率为88.45%.中药外敷治疗乳腺增生的效果显著优于乳癖消口服的治疗[OR=4.52,95%CI(1.98~10.33)].结论 中药外敷与中成药内服、灸法、按摩等疗效相当,而以行气活血、化痰通络为主要功效的中药外敷治疗乳腺增生的效果显著优于乳癖消口服的治疗,提示在临床工作中,可以根据患者所能接受的治疗手段进行治疗,以提高患者的满意度.

abstractsObjective To explore the effect of TCM external treatment on the patients with hyperplasia of mammary glands by meta-analysis.Methods Literatures about TCM external treatment on the patients with hyperplasia of mammary glands that were published on domestic or international magazines were extensively solicited and assessed with uniform effect criteria. The total number and valid number of patients in these literatures were counted, and the literatures were also assessed and chosen by meta-analysis with Review Manager 5.3.OR values and a 95% confidence interval (CI) were calculated and consolidated.Results Finally, totally 11 literatures and 945 patients were included in our study, of which 464 received TCM external treatment, an effective rate of 89.22%, while the control group included a total of 481 patients, an effective rate of 82.33%. TCM external treatment showed the same effect on hyperplasia of mammary glands as the oral liquid of Chinese medicines, massage and acupuncture did [OR=1.91,95%CI (0.74-4.97)]. When comparing the effect of TCM external treatment and Rupixiao oral liquid on hyperplasia of mammary glands, totally 6 literatures and 509 patients were included in the study, of which 258 received TCM external treatment, an effective rate of 97.29%, while 251 patients took Rupixiao oral liquid, an effective rate of 88.45%. TCM external treatment had a significantly better effect than Rupixiao oral liquid [OR=4.52,95%CI (1.98-10.33)].Conclusions TCM external treatment has the same effect with oral liquid of Chinese medicines, massage and acupuncture, while TCM external treatment on hyperplasia of mammary glands which promotes the circulation of qi and blood and eliminates phlegm and frees channels has a significantly better effect than Rupixiao oral liquid. It suggests that in our clinical work we should treat patients based on whatever methods they can withstand so as to improve their satisfaction.