摘要目的 比较不同雾化方式在AECOPD伴Ⅱ型呼吸衰竭持续无创正压通气患者中的应用效果,为患者雾化方式的合理选择提供参考依据.方法 便利选取AECOPD伴Ⅱ型呼吸衰竭持续无创正压通气患者150例,按住院时间分为观察组75例和对照组75例,对照组在无创正压通气时,采用雾化泵驱动进行标准的经口含式雾化,观察组将雾化吸入装置连接于口鼻面罩/鼻罩与呼吸机管路之间,在无创正压通气的同时吸入雾化药物.比较雾化吸入时和雾化后两组患者的氧饱和指标、心率、呼吸频率、呼吸困难、口干咽痛、排痰困难和舒适程度.结果 雾化后观察组心率(98.32±3.39)次/min、呼吸频率(23.16±1.30)次/min,分别低于对照组(100.18±3.16)、(25.67±1.21)次/min,差异均有统计学意义(t值分别为3.476、12.240;P<0.05).观察组口干咽痛(17.53±2.73)、排痰困难(20.49±3.71)以及舒适程度(17.81±4.47)分,分别高于对照组的(16.48±3.07)、(14.43±2.18)、(16.37±3.74)分,差异均有统计学意义(t值分别为2.213、12.196、2.140;P<0.05).结论 在持续无创正压通气过程中,无创呼吸机管路串联雾化吸入装置和口鼻面罩进行雾化吸入治疗,能提高患者的治疗效果和舒适度,降低带机不良反应程度.

abstractsObjective To compare the application effects of different aerosol inhalation methods of continuous non-invasive positive pressure ventilation (NIPPV)in the treatment of the patients with AECOPD combined withⅡ type respiratory failure and offer reference for the appropriate choice of patients' aerosol inhalation methods.Methods With the convenience sampling method, totals of 150 continuous NIPPV patients with AECOPD combined withⅡ type respiratory failure were divided into the observation group and the control group according to the hospitalization time (75 patients in each group). The patients in the control group used NIPPV and the standard oral spray driven by the atomizing pump. In the observation group the aerosol inhalation device was connected between the nasal face mask/nasal mask and the pipeline of the breathing machine. The patients in the observation group used NIPPV combined with the inhalation of atomizing drugs. Patients' oxygen saturation,heart rate, respiratory rate, dyspnea, dry mouth and sore throat, expectoration difficulties and comfort level in the two groups were compared between before and after the aerosol inhalation.Results After the aerosol inhalation,the heart rate and the respiratory rate in the observation group were (98.32±3.39)times/min and (23.16±1.30) times/min respectively, which were significantly lower compared with the control group [heart rate:(100.18±3.16)times/min,t=3.476,P<0.05; respiration rate: (25.67±1.21) times/min,t=12.240,P<0.05].The scores of dry mouth and sore throat, expectoration difficulties, and the comfort level in the observation group were (17.53±2.73), (20.49±3.71)and (17.81±4.47),which were significantly higher compared with the control group [dry mouth and sore throat:(16.48±3.07),t=2.213,P<0.05; expectoration difficulties:(14.43±2.18),t=12.196,P<0.05; comfort level:(16.37±3.74),t=2.140,P<0.05].Conclusions In the process of the continuous NIPPV, the aerosol inhalation device and nasal face mask are connected in the pipeline of the non-invasive breathing machine for the aerosol inhalation treatment, which can improve the therapy effect and the comfort level for patients and decrease the adverse effect level due to the use of the breathing machine.