摘要目的?探讨快速康复护理对胰十二指肠切除患者术后早期血栓风险的影响.方法?采用便利抽样,以2016年9月—2017年3月采取传统护理方式的45例胰十二指肠切除术患者作为对照组,以2017年3月—2018年6月实施快速康复护理的66例胰十二指肠切除术患者作为干预组.收集术前、术后即刻、术后第1天、术后第2天、术后第3天、术后第7天D-二聚体值,比较两组术后D-二聚体值及症状性血栓发生率.结果?干预组术后即刻、术后第1天、术后第2天、术后第3天、术后第7天D-二聚体值分别为(2.74±2.31)、(3.31±2.03)、(3.98±3.10)、(4.30±2.89)、(7.46±3.90)mg/L·FEU,对照组术后各时间点D-二聚体分别为(2.88±1.92)、(3.77±2.72)、(4.37±2.70)、(4.08±1.81)、(6.85±4.07)mg/L·FEU,两组术后D-二聚体值整体呈上升趋势,但两组间差异无统计学意义(P＞0.05);重复测量方差分析结果显示,两组术后D-二聚体组间效应(F=0.03,P=0.87)及交互效应(F=1.01,P=0.38)差异无统计学意义,时间效应(F=108.28,P＜0.05)差异有统计学意义.两组患者症状性血栓发生率比较差异无统计学意义(χ2=0.87,P＞0.05).结论?胰十二指肠切除术后早期血栓风险持续增高,且快速康复护理较传统方式在改善胰十二指肠切除术后早期血栓风险方面无明显优势.

abstractsObjective? To explore the effects of enhanced recovery nursing on early postoperative vein thromboembolism (VTE) risk after pancreaticoduodenectomy (PD). Methods? Using convenience sampling method, the 45 cases of PD patients with traditional nursing methods from September 2016 to March 2017 were assigned as the control group, and the 66 cases of PD patients with enhanced recovery nursing from March 2017 to June 2018 were assigned as intervention group. The plasma D-dimer level before operation, immediately after operation, and in different postoperative days (POD): POD1, POD2, POD3 and POD7 were collected. The D-dimer level and the incidence rates of symptomatic VTE were compared between two groups. Results? The D-dimer values of the intervention group immediately after surgery, POD1, POD2, POD3 and POD7 were (2.74±2.31), (3.31±2.03), (3.98±3.10), (4.30±2.89) and (7.46±3.90) mg/L·FEU. The D-dimer of the control group at each postoperative time point were (2.88±1.92), (3.77±2.72), (4.37±2.70), (4.08±1.81) and (6.85±4.07) mg/L·FEU. The overall D-dimer value of the two groups showed an upward trend after operation,but there was no significant difference between two groups (P＞0.05). Repeated measures analysis of variance showed that there were no differences in between-group effect (F=0.03, P=0.87) or interaction effect (F=1.01,P=0.38) of D-Dimer, while the difference in intra-group effect was statistically significant (F=108.28, P＜ 0.05). There was no statistical significance in the difference of the incidence rates of symptomatic VTE between two groups (χ2=0.87, P＞ 0.05). Conclusions? The early postoperative VTE risk after PD gradually increased, and the enhanced recovery nursing show no significantly advantage in VTE risk reduction after PD compared to traditional methods.