摘要目的:探讨癫痫患儿父母感知脆弱（PPCV）与患儿焦虑在父母社会支持与患儿生活质量间的中介效应。方法:本研究为横断面研究。采用便利抽样法，选取2021年9月—2022年4月在上海市儿童医院神经内科门诊行视频脑电图检查的315例癫痫患儿及315名癫痫患儿父母为研究对象，采用一般资料调查表、感知脆弱程度量表（CVS）、社会支持评定量表（SSRS）、PROMIS父母报告版焦虑简表、健康相关生活质量量表（QOLCE-16）对患儿父母进行调查。采用Pearson相关性分析癫痫患儿生活质量与父母社会支持、PPCV、患儿焦虑的相关性；采用AMOS 22.0软件建立结构方程模型并分析变量间关系。本研究共发放问卷315份，回收有效问卷295份，有效回收率为93.7%。结果:295名癫痫患儿父母的SSRS得分为（40.75±10.24）分、CVS得分为（8.08±4.84）分、PROMIS父母报告版焦虑简表得分为（16.40±5.98）分、QOLCE-16得分为（72.01±15.43）分。父母社会支持与PPCV、患儿焦虑均呈负相关（ P均<0.01），PPCV、患儿焦虑与患儿生活质量均呈负相关（ P均<0.01），父母社会支持与患儿生活质量呈正相关（ P<0.01）。PPCV与患儿焦虑在父母社会支持与患儿生活质量间起中介作用（ P<0.01），父母社会支持对患儿生活质量的直接效应与间接效应分别为0.301、0.205。 结论:父母社会支持可直接影响患儿生活质量，也可通过PPCV和患儿焦虑间接影响患儿生活质量。临床护理工作者应对癫痫患儿及其父母给予更多的关怀与支持，帮助其加深对疾病的认知，减轻PPCV与患儿焦虑水平，从而改善癫痫患儿生活质量。

abstractsObjective:To explore the mediating effects of parental perceptions of child vulnerability (PPCV) and child anxiety in the relationship between parental social support and the quality of life in children with epilepsy.Methods:This was a cross-sectional study. Totally 315 children with epilepsy and their 315 parents who visited the neurologic outpatient clinic for video EEG monitoring from September 2021 to April 2022 were selected by convenience sampling and investigated with General Information Questionnaire, Child Vulnerability Scale (CVS), Social Support Rating Scale (SSRS), PROMIS Parents Report Anxiety Short Form, and the Quality of Life in Children with Epilepsy-16 (QOLCE-16). Pearson correlation was used to analyze the relationships between quality of life in children with epilepsy and variables such as parental social support, PPCV, and child anxiety. AMOS 22.0 was utilized to establish a structural equation model to examine the relationships among the variables. A total of 315 questionnaires were distributed, with 295 valid questionnaires retrieved, yielding a response rate of 93.7%.Results:The scores for the 295 parents on the SSRS, CVS, PROMIS Parents Report Anxiety Short Form, and QOLCE-16 were (40.75±10.24), (8.08±4.84), (16.40±5.98), and (72.01±15.43), respectively. Parental social support was negatively correlated with PPCV and child anxiety ( P<0.01), and both PPCV and child anxiety were negatively correlated with the child's quality of life ( P<0.01), while parental social support had a positive correlation with the child's quality of life ( P<0.01). PPCV and child anxiety mediated the relationship between parental social support and the child's quality of life ( P<0.01), with the direct and indirect effects being 0.301 and 0.205 respectively. Conclusions:Parental social support can directly affect the quality of life of children with epilepsy, and also indirectly influence it through PPCV and child anxiety. Clinical nursing staff should provide more care and support for children with epilepsy and their parents, helping to deepen their understanding of the disease, reduce levels of PPCV and child anxiety, thereby enhancing the quality of life for children with epilepsy.