摘要目的:总结成人家庭肠外营养安全管理的最佳证据。方法:计算机检索UpToDate、国际指南协作网、美国国立指南网、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、Cochrane Library、PubMed、Web of Science、中国知网、万方数据库、中国生物医学文献数据库等，筛选有关成人家庭肠外营养安全管理的文献，包括临床决策、指南、证据总结、专家共识、系统评价、Meta分析等，检索时限为建库至2023年12月30日。由2名接受过循证护理培训的研究人员进行文献质量评价和证据提取。结果:共纳入14篇文献，包括3篇指南、6篇专家共识、1篇医院标准和4篇Meta分析。最终从团队组建、过渡期护理、并发症预防及管理、监测随访与质量控制4个方面总结了33条证据。结论:本研究总结了成人家庭肠外营养安全管理的最佳证据，医护人员应结合临床情景和患者意愿选择、应用证据。

abstractsObjective:To summarize the best evidence for safely managing home parenteral nutrition in adults.Methods:Clinical decisions, guidelines, evidence summaries, expert consensus, systematic reviews, Meta-analyses, and so on related to the safety management of home parenteral nutrition in adults were electronically retrieved on UpToDate, Guidelines International Network, Agency for Healthcare Research and Quality, Joanna Briggs Institute Evidence-Based Health Care Center Database, Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure, WanFang Data, China Biology Medicine disc and so on. The search period was from database establishment to December 30, 2023. Two researchers who received evidence-based nursing training conducted literature quality evaluation and evidence extraction.Results:A total of 14 articles were included, including three guidelines, six expert consensus, one hospital standard, and four meta-analyses. Thirty-three pieces of evidence were summarized from four aspects: team building, transitional care, preventing and managing complications, monitoring, follow-up, and quality control.Conclusions:The best evidence for safety management of home parenteral nutrition in adults is summarized. Medical and nursing staff should select and apply evidence based on clinical scenarios and patient preferences.