摘要Objective To observe the relationship of sibelium between vasodilatlting and vasoconstricting factors, and the treating and preoeating effect of sibelium on migraine in women Methods 60 women wre randomly divided into the xueshuantong group( n= 30) and sibelium group(n = 30). We compared the therapeutic effect in the two groups, detected endothelins(ET) and calcitonin gene - related peptide (CGRP) in blood before and after treatment Results In sibelium group, the concentration of CGRP after treatment was lower than that before treatment.Sibelium lightened the extent of heodoche, reduced the duration of headache( both effciency rate of 93% ). Xueshuantong could only lighten the degree of headache(effuctive rate: 70% ). Conclusion Sibelium could control the attack of migraine in women without obvious side effect.