摘要目的 通过家猪实验,研究消融阻隔气囊在肝脏射频消融治疗中的保护作用.方法 5只猪全麻后在CT引导下行射频消融治疗,针对消融阻隔气囊的保护作用行随机对照实验研究.每只猪均取两个治疗区,实验区加用消融阻隔气囊保护,对照区不用阻隔气囊.术后3～4 d处死猪.观察组织坏死病理变化并测量坏死组织面积.结果 实验组和对照组各有5个治疗区,实验组消融时间为(18.2±2.6)min,肝坏死组织的最大直径为(4.9±0.5)cm;对照组消融时间为(16.0±1.8)min,肝组织坏死最大直径为(4.6±0.6)cm,两组治疗时间和肝组织坏死最大直径差异无统计学意义(P>0.05).实验组无膈肌损伤,对照组膈肌均有热损伤.膈肌损伤面积平均(5.2±2.0)cm2,两例出现穿孔.结论 消融阻隔气囊可在行射频消融时有效保护邻近器官,减少热损伤并发症.

abstractsObjective To evaluate protective effect of using ablation-separating balloon during liver radiofrequence ablation(RFA) in swine. Methods Five swines were received liver RFA under real-time CT guidance after general anaesthesia. A randomized control trial about protective effect of using ablation-separating balloon was carried out. Each swine received twice RFA in its liver adjacent to diaphragm. Experimental region was protected with ablation-seperating balloon, and control region was treated without protection. The swines were sacrificed 3 to 4 d after RFA. Pathologic changes were observed and liver necrosis area was measured. Results Every group had 5 regions of RFA. Average duration of RFA in experimental group was (18.2±2.6) min, and that in control group was (16.0±1.8) min. The maximum diameter of liver necrosis in experimental group was (4.9± 0.5) cm, and that in control group was (4.6±0.6) cln. The average duration of RFA and maximum diameter of liver neocrosis had no significant difference (P>0.05). There was no diaphragmatic thermal injury in experimental group, but diaphragmatic thermal injury was observed in all the swines in control group. The average injury area of diaphragm was (5.2±2.0) cm2, and perforation of diaphragm took place in two swines. Conclusion The ablation-seperating balloon can effectively protect adjacent tissue to target organ of RFA, and reduce complications of thermal injury.